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KMID : 0385019920080020207
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Korean Journal of Laboratory Animal Science
1992 Volume.8 No. 2 p.207 ~ p.211
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Acute Toxicity of Porcine Somatotrophin in Rats and Mice
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Abstract
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This study was carried rout to investigate the acute toxicity of porcine somatotrophin(PST) in both sexes of Sprague-Dawley rats and ICR mice. The PST is a recombinent porcine growth hormone, and was subcutaneously given to rats and mice up to 1000 times of clinical dosage(0.1 ㎎/㎏ B.W. in porcine). PST did not induce any toxicological effect such as mortality. clinical findings, gross findings and body weight changes in rats and mice. It was estimated that LD_(50) value was over 100 ㎎/㎏ B.W.
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KEYWORD
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